Mesothelioma Attorney New York
More than 20 million people in the U.S., and many more around the world who have been exposed to asbestos are at risk of developing mesothelioma, a malignant cancer of the membranes covering the lungs and abdomen that is resistant to current therapies. On the other hand, exposure to asbestos increases the risk of lung cancer among smokers. Over the past 40 years researchers have tried to understand what causes cancer of asbestos.
Although Canada was one of the first countries to ban asbestos handling a severe regulation is now a major exporter to countries that begin their development and where there is no legislation restricting these products as India , Mexico and several African countries and their respective markets and areas of influence. This attitude has generated numerous international protests.
The answer appears in a study published in the current issue of the Proceedings of the National Academy of Sciences, USA, Drs. Haining Yang and Michele Carbone at the University of Hawaii Cancer Research Center led a research team that included colleagues at the University of New York, the University of Chicago, University of Pittsburgh, San Raffaele University of Milan, and the Imperial College in London.
Picture of cancer caused by asbestos
These researchers focused on the paradox of how asbestos fibers that kill cells can cause cancer, as a dead cell should not be able to grow and form a tumor.
They found that when asbestos kills cells, it does so by inducing a process called “programmed cell necrosis,” which leads to the release of a molecule called high mobility group box 1 protein (HMGB1).
HMGB1 starts a particular type of inflammatory reaction that triggers the release of mutagens and factors that promote tumor growth. The researchers found that patients exposed to asbestos have elevated levels of HMGB1 in the serum. So, say it is possible to orient the HMGB1 to prevent or treat mesothelioma and identify asbestos-exposed cohorts by simple HMGB1 serological testing.
In the article, the researchers propose that by interfering with the inflammatory reaction caused by asbestos and HMGB1, it may be possible to decrease the incidence of cancer among asbestos-exposed generations and reduce the rate of tumor growth among those already affected by mesothelioma. The Dres.Yang and Carbone, lead authors, state that to test this hypothesis, and are planning a clinical trial in a remote area in Cappadocia, Turkey, where over 50% of the population dies of malignant mesothelioma. If results are positive, the approach will be extended to cohorts of people exposed to asbestos in the U.S.
This research highlights the role of inflammation in causing different types of cancer and provide new clinical tools to identify exposed individuals and prevent or reduce tumor growth. Researchers wonder whether we can prevent this cancer, like colon cancer, using a simple aspirin or similar drugs that stop inflammation. You are about to test this hypothesis.
In Mexico, the story is different, studies like the National Institute of Public Health (INSP) released in 2000, ensure that 80 percent of mesothelioma cases undergoing review by the agency did not show ” no direct relationship of these with exposure to asbestos from 1991 to 1998. ” However, in the sixth report of the World Health Organization (WHO) 2004, on “Occupational Carcinogens” and the burden they represent to the nations, reports that malignant mesothelioma is directly related to asbestos exposure, do As was the bite that gave Mexalit?
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